High level ciprofloxacin resistance in Neisseria gonorrhoeae.

Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains from Shandong Province, China

In the study, the ciprofloxacin resistance rate was 100%. High-level ciprofloxacin resistance rate was 63.55%. Sixteen different mutation patterns involved in the formation of ciprofloxacin resistance were identified. The most prevalent were patterns P7 (25.2%), P8 (15.0%), P9 (11.2%), P1 (10.3%), and P5 (10.3%). All of the 107 NG isolates analyzed for mutations in the study have demonstrated a...

High-level ciprofloxacin resistance in Neisseria gonorrhoeae: first report from Israel.

To the Editor: We report a case of male gonococ-cal urethritis that persisted despite ciprofloxacin therapy. The isolate was found to be highly resistant (MIC 32 µg/mL). A 30-year-old man visited his family physician with a 2-day history of urethral discharge and dysuria. The symptoms began 7 days after a single, unprotected orogenital contact with a female hitchhiker. The patient denied exchan...

Ciprofloxacin resistant Neisseria gonorrhoeae.

Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains isolated in Denmark from 1995 to 1998.

In Denmark surveillance of the in vitro susceptibility to ciprofloxacin of Neisseria gonorrhoeae was established in 1990. The proportion of N. gonorrhoeae strains with decreased susceptibility or resistance to ciprofloxacin (MIC >/= 0.06 microg/ml) was low (0.3 to 2.3%) up to 1995. Between 1995 and 1998 the rate of less-susceptible and resistant strains rose from 6.9 to 13.2%. Among ciprofloxac...

Laboratory detection of ciprofloxacin resistant Neisseria gonorrhoeae.

During 1989 and 1990 strains of Neisseria gonorrhoeae with reduced susceptibility to ciprofloxacin were isolated in laboratories across the United Kingdom. Treatment failures were associated with some of these infections. These strains were detected by quantitative susceptibility testing because the zone of inhibition around 5 micrograms ciprofloxacin discs shows little decrease in size even wi...